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Here at MM411, our focus is to provide science-based medical reports on the healing potential of marijuana. We understand that marijuana can be confusing topic. Some believe it should be banned in all forms, while others argue for complete legalization and taxation. We believe there is a need for that debate, however, this site is not that place. Our purpose is to inform.
A Brief History of Medical Marijuana
In 1990, the cannabinoid receptor was first discovered in the human brain and by 1992 the entire endocannabinoid system had been uncovered. With this, science glimpsed the potential medicinal benefits of marijuana for the first time.
Since then these potential medicinal uses have been well documented.
According to Harm Reduction Journal’s report titled “Harm Reduction – The Cannabis Paradox”, cannabinoids
“regulate intercellular communication, especially in the immune and nervous systems,” as well as “modulate and coordinate tissues, organ and body systems (including cardiovascular, digestive, endocrine, excretory, immune… and respiratory systems).”
Medical Marijuana is one of our more useful medicines, as The Institute of Medicine points out in their book, Marijuana and Medicine: Assessing the Science Base (1999)
Cannabinoids likely have a natural role in pain modulation, control of movement, and memory… “The combination of cannabinoid drug effects (anxiety reduction, appetite stimulation, nausea reduction, and pain relief) suggests that cannabinoids would be moderately well suited for particular conditions, such as chemotherapy-induced nausea and vomiting and AIDS wasting.”
The Endocannabindoid System – This ancient system found in all vertebrate maintains homeostasis within and across the organizational scales of all animals, including humans, and includes the Cb1 and Cb2 receptors. Within a cell, cannabinoids control basic metabolic processes such as glucose metabolism . Cannabinoids regulate intercellular communication, especially in the immune  and nervous systems . In general, cannabinoids modulate and coordinate tissues, organ and body systems (including the cardiovascular , digestive , endocrine , excretory [7,8], immune , musculo-skeletal , nervous , reproductive , and respiratory  systems). The effects of cannabinoids on consciousness are not well understood, but are well known, and underlie recreational cannabis use. These effects also have therapeutic possibilities .
Endocannabinoids – Cannabinoids produced by the body.
Photocannabinoids – Cannabinoids produced by the plant.
Cb1 Receptor - Primarily found in the brain.
Cb2 Receptor – Primarily found in the immune system.
AEA (Anandamide) – An endogenous cannabinoid neurotransmitter found in organs (human and most animals), with an abundant amount located in the brain. (While delta-9-tetrahydrocannabinol (THC) was first synthesized by Mechoulam in 1967 , it was not until 1990 that the cannabinoid receptor was localized in the brain  and cloned . Since then, discoveries in the field have proceeded at an ever-increasing pace.)
THC (Tetrahydocannabinol) – The psychoactive cannabinoid found in the plant. Also useful in cancer treatment options, appetite stimulation, nausea reduction, cancer cell growth reduction, among others.
CBD (Cannabidiol) – Very helpful in cannabinoid treatment options in an array of conditions including epilepsy, inflammatory conditions, reduction in cancer cell growth, appetite suppression, among many others. Also found in the plant.
CBN (Cannabinol) – Anticonvulsant, lowers heart rate, decreases blood clotting. Produced through THC degradation (so store your cannabis in an airtight container and in a cool, dark place) and less psychoactive than THC. Affinity to Cb2 receptor.
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