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Cannabinoids, the active ingredients in marijuana, have dramatic effects on various organ systems. They exert their effects through two receptor types: CB1, primarily located in the brain, and CB2, primarily located in the immune system.
Vertebrates also produce their own cannabinoid-like substances called endocannabinoids, including anandamide and 2-arachidonoylglyceral. Interestingly, some effects of endocannabinoids could not be explained by the signals through either CB1 or CB2.
Recently, the orphan G protein-coupled receptor 55 (GPR55) was proposed to be an atypical cannabinoid receptor.
Two groups demonstrated that GPR55 is expressed in various cancer types in an aggressiveness-related manner, suggesting a novel cancer biomarker and a potential therapeutic target.
Cannabis Reduces Infant Mortality Surprising Connections Between Failure to Thrive and Cannabinoids (NORTHERN CALIFORNIA) – Years ago, a friend of mine, a good Christian lady, had a child with “failure to thrive”. She had CPS all over her, looking for even the tiniest trace of child neglect. They found none. The child was well cared
Hi, I’m Dr Robert Melamede PhD. I’m a professor at the University of Colorado at Colorado Springs. I was the former chairman of the biology department there. And currently in addition to my role as professor I am also the CEO and president of Cannabis Science a publicly traded company on the NASDAC bulletin board (CBIS). I was studying free radicals in that I was studying radiation chemistry and DNA repair. So that gave me a foundation to understand free radicals as very important modulators, essentially of aging and age related illnesses. Which is really what cannabis does. So, by combining my understanding of life from the thermodynamic point of view, pharma-equilibrium thermodynamic point of view in conjunction with my expertise in radiation chemistry and free radicals and being a lifelong cannabis user, I have been in a very unique position to assemble those three entities into a cohesive perspective as to what life is and the fundamental role that the endocannabinoid system plays in life and how it modulates a imbalance we all suffer.
Medical use of cannabis has taken on momentum of its own, surging ahead of scientists’ ability to measure the drug’s benefits. The pace has been a little too quick for some, who see medicinal joints as a punch line, a ruse to free up access to a recreational drug.
But while the medical marijuana movement has been generating political news, some researchers have been quietly moving in new directions — testing cannabis and its derivatives against a host of diseases. The scientific literature now brims with potential uses for cannabis that extend beyond its well-known abilities to fend off nausea and block pain in people with cancer and AIDS. Cannabis derivatives may combat multiple sclerosis, Crohn’s disease and other inflammatory conditions, the new research finds. Cannabis may even kill cancerous tumors.
Endocannabinoids this is the short name for endogenous cannabinoids. Cannabinoids is a compound, which acts on two receptors. One receptor is found mainly in the brain, the other receptor is found mainly in the periphery. But, surprisingly, or maybe not so surprisingly, during certain diseases the second receptor that is not present in the brain starts to pop up. All of a sudden it is available there. So the suggestion has been made by many others, and us that actually this receptor, the Cb2 receptor, is part of a protective mechanism. We have protective systems in our body. The immune system is a protective system. It guards us against microbes and viruses things like that. If we didnt have an immune system, we would be dead in a week. Probably eaten up by microbes.
Science has found two cannabinoid receptors, CB1 and CB2 (so far) as part of our ‘receptor’ category within the human endocannabinoid system but with further research we’ll soon begin to understand much more about this system (internal compounds much like marijuana). This system also includes degradation, synthesis, and transport. Some of these compounds date back roughly 600 million years and can be found in hundreds of life forms and it is through these life forms that this system evolved with us.
There are a group of researchers around the world, that are very interested in the endocannabinoid system, interested in how that works, how it functions. Elger is one of those people. He and another PHD named Nichol wrote an article that appeared in Scientific America which I believe is entitled The Brains on Marijuana. We have discovered, we meaning scientists not me, at least two endocannabinoids, two different 21 carbon molecules that have receptor sites that can be stimulated by Cannabis. And Cannabis of course, has 66, at least 66 cannabinoids and those are 21 carbon molecules that may have different side chain and every time you have a different side chain you have a different substance.
My name is Sunil Aggarwal. I am a trainee in the medical scientist program at the University of Washington, 4th year medical student, I hold a PhD in medical geography. Recently I was a medical student delegate to the American Medical Association. Cannabis is a botanical medicine that has an established track record of safety, non-toxicity, for 3 millennia of documented history. And effectiveness that’ been shown in numerous highly randomized control trials, all the way to case reports from numerous cultures around the world. Plus the psychologically activating properties of cannabis, which I thought, were important for stress reduction and quality of life. Plus it’s discovery, it helped caused us to discover a signaling system, in humans and throughout most living organisms, called the cannabinoid signaling system which was fascinating from a neuro-scientific standpoint for me.