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The Putative Cannabinoid Receptor GPR55 Promotes Cancer Cell Proliferation

Daily Dose 2010-11-15 0 comments

By Hu GRen GShi Y, posted in

Cannabinoids, the active ingredients in marijuana, have dramatic effects on various organ systems. They exert their effects through two receptor types: CB1, primarily located in the brain, and CB2, primarily located in the immune system.

The proteins involved in the endocannabinoid system; CB1 and CB2 receptors. (Photo Credit:

Vertebrates also produce their own cannabinoid-like substances called endocannabinoids, including anandamide and 2-arachidonoylglyceral. Interestingly, some effects of endocannabinoids could not be explained by the signals through either CB1 or CB2.

Recently, the orphan G protein-coupled receptor 55 (GPR55) was proposed to be an atypical cannabinoid receptor.

Two groups demonstrated that GPR55 is expressed in various cancer types in an aggressiveness-related manner, suggesting a novel cancer biomarker and a potential therapeutic target.