Dr. Raphael Mechoulam has continued his cannabis research and made discoveries that help to create an understanding of the benefits of the cannabis plant.
These two receptors that are specific to cannabinoids. But cannabinoids also, some of them bind to other receptors. There is one-called 133 I think, GPR133, there is another one, which is GPR18. I may be mistaken on the numbers, but I think GPR18, GPR133 and so on. They are not specific for the cannabinoids so there is a lot of discussion between the pharmacologists should we call them cannabinoid receptors. The decision at the moment is lets wait and sees. At the moment we have only two that have been approved as cannabinoid receptors. All the others with a question mark. Two receptors have evolved for certain specific conditions, feeding for example, appetite, feeding, and things of that sort. But some of the other actions most definitely go through other systems.
My name is Raphael Mechoulam. Im a professor at Hebrew University. I have been there for many years. Im doing research on the chemistry and biology of natural products, mostly, but also some drugs. There is no drug that has no side effects. I doesnt exist. The same is probably true for cannabis. Now being a chemist, I was particularly interested in the individual constituents of the plant. Surprisingly, the constituents of the cannabis plant were not well known when we started work many years ago, several decades ago. The psychoactive component of cannabis was not known at that time, surprisingly, again. Because morphine had been isolated from opium about 150 years before that, cocaine about 100 years before that, and yet the active component of cannabis had never been isolated in pure form.
I was asked by my Parliament, the parliament is called the Knesset, to head a committee to decide to go ahead with cannabis both a medicinal agent and so on and there was a committee of government officials mostly, and I was the only one from the outside so I was chairman. And we wrote a big report that said that it should be utilized as a medicinal agent. And more research would be done and also young people should not be sent to prison, or convicted, or criminal files should not be opened, to make things more tolerable. And although it never became a law, and government officials who were in charge of these things, apparently instructed the police to follow these recommendations. So since then, to the best of my knowledge, young people who were caught smoking pot, they were scolded, were told, you, you have a lot of problems, but they never opened a criminal file, they never appeared in court, they never were sent to prison, the reason was, it makes sense.
Dr. Raphael Mechoulam – Cannabis During Pregnancy Raphael Mechoulam (Hebrew: רפאל משולם) (born 1930) is an Israeli organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel. Mechoulam is best known for his work (together with Y. Gaoni) in the isolation, structure elucidation and total synthesis of Δ9-tetrahydrocannabinol, the main