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Medical Cannabis is Sweeping Our Nation
Daily Dose 2010-05-19

Medical Cannabis is Sweeping Our Nation

Mark Pedersen is a Founder of Sensible Missouri and Cannabis Patient’s Network, and is a contributing writer for Medical Marijuana 411. Look for his Patient Story online shortly.

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Osteoporosis and Research
Daily Dose 2010-05-07

Osteoporosis and Research

There are many aspects that one can talk about. One is the basic biochemical, pharmacological, scientific aspect of the whole problem. Here we have a new neurotransmitter. A group of compounds that have a huge amount of tasks if we look at the chemically related compound, I made a list of that, these compounds are involved almost all physiological reactions. So many of them, That I think here there is so much work to be done by scientists over the next 20, 30, 40 years. A lot of those compounds are around, some of them bind to the cannabinoid receptors, others are just chemically related and bind to other receptors are involved in many many other things. And I mentioned before, those that bind to the Cb2 receptors are part of a general protective facility, if you wish, in our body like the immune system. So that is the basic thing, then there is the medical thing, we have to find out how we can use them and what are the diseases we can use these compounds against.

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Osteoporosis
Daily Dose 2010-05-07

Osteoporosis

These two receptors that are specific to cannabinoids. But cannabinoids also, some of them bind to other receptors. There is one-called 133 I think, GPR133, there is another one, which is GPR18. I may be mistaken on the numbers, but I think GPR18, GPR133 and so on. They are not specific for the cannabinoids so there is a lot of discussion between the pharmacologists should we call them cannabinoid receptors. The decision at the moment is lets wait and sees. At the moment we have only two that have been approved as cannabinoid receptors. All the others with a question mark. Two receptors have evolved for certain specific conditions, feeding for example, appetite, feeding, and things of that sort. But some of the other actions most definitely go through other systems.

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Dr. Raphael Mechoulam
Daily Dose 2010-05-07

Dr. Raphael Mechoulam

My name is Raphael Mechoulam. Im a professor at Hebrew University. I have been there for many years. Im doing research on the chemistry and biology of natural products, mostly, but also some drugs. There is no drug that has no side effects. I doesnt exist. The same is probably true for cannabis. Now being a chemist, I was particularly interested in the individual constituents of the plant. Surprisingly, the constituents of the cannabis plant were not well known when we started work many years ago, several decades ago. The psychoactive component of cannabis was not known at that time, surprisingly, again. Because morphine had been isolated from opium about 150 years before that, cocaine about 100 years before that, and yet the active component of cannabis had never been isolated in pure form.

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Dr. Raphael Mechoulam
Daily Dose 2010-05-07

Dr. Raphael Mechoulam

Endocannabinoids this is the short name for endogenous cannabinoids. Cannabinoids is a compound, which acts on two receptors. One receptor is found mainly in the brain, the other receptor is found mainly in the periphery. But, surprisingly, or maybe not so surprisingly, during certain diseases the second receptor that is not present in the brain starts to pop up. All of a sudden it is available there. So the suggestion has been made by many others, and us that actually this receptor, the Cb2 receptor, is part of a protective mechanism. We have protective systems in our body. The immune system is a protective system. It guards us against microbes and viruses things like that. If we didnt have an immune system, we would be dead in a week. Probably eaten up by microbes.

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Investigation of Cannabinoids
Daily Dose 2010-05-07

Investigation of Cannabinoids

Our non-profit organization that we set up about 2 years ago has been doing a lot of work educating physicians around the medical cannabis issue. We have realized there is a need for physicians to be taught more and they really appreciate hearing it from other physicians, who either have experience with patients, who are doing research like myself. And this group, its call the Canadian Consortium for the Investigation of Cannabinoids, its a fairly big mouthful, but the CCIC for short, is the group, and that has been really rewarding.

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Cannabis As Medicine
Daily Dose 2010-05-07

Cannabis As Medicine

I think that as we accept the medical utility of cannabis. We are going to start to dig more deeply in to the cannabinoids the key constituents of the marijuana plant that are providing this benefit. From a pharmaceutical company perspective, I think there is going to be an interest in trying to isolate those compounds. Or trying to work within the endogenous cannabinoids system that system of cannabinoids, which is functioning within all of us all the time with, out any external influence. Trying to target that with medications that can up regulate the level of cannabinoids in our bodies can eliminate the break down of cannabinoids. So perhaps getting a cannabinoid effect without really taking in a cannabinoid but by enhancing our own endogenous levels. So I think that is one area the pharmaceutical industry is going to be taking. I think another area is trying to improve the over all quality and regulation of herbal cannabis.

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Cannabis Compared To Opiate-Based Medicines
Daily Dose 2010-05-05

Cannabis Compared To Opiate-Based Medicines

Dr. Donald Abrams Compares Cannabis To Opiate-based Medicines Donald Abrams, M.D. explains he first…

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Cannabinoids and the Immune System
Daily Dose 2010-04-27

Cannabinoids and the Immune System

Cannabinoids are immune system modulators, with the specific CB2 cannabinoid receptor found on most cells on the immune system, promoting the Th2 response while inhibiting the Th1 response. The Th1 immune response is critical for fighting infections caused by specific infectious agents while the Th2 response promotes the humoral arm of the immune system. It turns down the Th1 immune response, is characterized by antibody production, and is typically anti-inflammatory. The Th1 and Th2 pathways are functionally balanced to optimally meet the survival needs of an organism in its environment. Many autoimmune and other age-related diseases (such as MS, arthritis, Crohn’s disease, and diabetes) are characterized by an excessive Th1-driven immune response at the site of the tissue damage involved.

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Endocannabinoid System - Vital Role In Human Body
Daily Dose 2010-04-08

Endocannabinoid System - Vital Role In Human Body

Science has found two cannabinoid receptors, CB1 and CB2 (so far) as part of our ‘receptor’ category within the human endocannabinoid system but with further research we’ll soon begin to understand much more about this system (internal compounds much like marijuana). This system also includes degradation, synthesis, and transport. Some of these compounds date back roughly 600 million years and can be found in hundreds of life forms and it is through these life forms that this system evolved with us.

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Cannabis, Cannabinoids - ADD & Tourettes
Daily Dose 2010-04-02

Cannabis, Cannabinoids - ADD & Tourettes

Earlier you mentioned that maybe I was opposed to medical marijuana and I said no I was just dubious. And I certainly was dubious about the use of cannabis in treating ADD/ ADHD. But that was because I didn’t know anything and when I looked into it, I found out that there were at least 40 papers written before 2000 dealing with the endo-cannabinioid system, cannabis, and ADD/ ADHD. And that as early as 1998 efforts had been made in Oregon to add ADD/ ADHD to the list of conditions for which cannabis was appropriate or legal in the state of Oregon. I began to have people mention that they were able to focus and concentrate more with cannabis. I had people tell me that their grades went from Ds and Fs to As and Bs when they started using marijuana in Jr High School. I had one patient come in and attributed their graduating from the maritime academy to smoking marijuana. And another person who said that they were able to get their PHD as a result of smoking marijuana. I started looking into this and found that there were hundreds of research studies that had been done which provided some of the information as to why this might work.

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David Bearman - Medicinal Benefits of Cannabis
Daily Dose 2010-04-02

David Bearman - Medicinal Benefits of Cannabis

There are a group of researchers around the world, that are very interested in the endocannabinoid system, interested in how that works, how it functions. Elger is one of those people. He and another PHD named Nichol wrote an article that appeared in Scientific America which I believe is entitled The Brains on Marijuana. We have discovered, we meaning scientists not me, at least two endocannabinoids, two different 21 carbon molecules that have receptor sites that can be stimulated by Cannabis. And Cannabis of course, has 66, at least 66 cannabinoids and those are 21 carbon molecules that may have different side chain and every time you have a different side chain you have a different substance.

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Dr. Sunil Aggarwal Discusses The Geography of Medical Marijuana
Daily Dose 2010-03-08

Dr. Sunil Aggarwal Discusses The Geography of Medical Marijuana

My name is Sunil Aggarwal. I am a trainee in the medical scientist program at the University of Washington, 4th year medical student, I hold a PhD in medical geography. Recently I was a medical student delegate to the American Medical Association. Cannabis is a botanical medicine that has an established track record of safety, non-toxicity, for 3 millennia of documented history. And effectiveness that’ been shown in numerous highly randomized control trials, all the way to case reports from numerous cultures around the world. Plus the psychologically activating properties of cannabis, which I thought, were important for stress reduction and quality of life. Plus it’s discovery, it helped caused us to discover a signaling system, in humans and throughout most living organisms, called the cannabinoid signaling system which was fascinating from a neuro-scientific standpoint for me.

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Dr. Mark Ware Discusses Cannabis As Medicine
Daily Dose 2010-03-07

Dr. Mark Ware Discusses Cannabis As Medicine

I first became familiar with about 10 years ago, when I beginning to explore the area of medical cannabis research, writing up grants, doing interviews with patients and beginning to explore this. I became aware that there was this conference being held at I think at the University of Iowa the first one, I didnt have any funding to get there. So I called them up and I said, is there a video link up, is there some way I can dial into this to watch it from Montreal where I was based. And I was able to speak to McGill, and they lent me a room, a video screen and a projector. And I watched the whole thing sitting a room, there were three or four of us sitting this room and watched the whole congress. I was amazed in the level of science, and the stories, the patient involvement. What I really liked was the patient involvement. And even today when I gave my talk, I ask the room how many people were patients in the room. And over half the room was patients. And most of the talks that I do, the conferences I go are working with the phycisions and scientists. And its really rewarding to speak to patients, meet them afterward and interact and get a sense of from them to see the level of interest they have in getting that knowledge. So I think I like the patients out of time, because of the patients that are in there. I think that is the critical piece for me.

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